Previous longitudinal bone density studies suggest that lactation is associated with reversible bone loss Sowers et al. However, it is not clear whether this loss of bone density is simply due to the relative oestrogen deficiency of lactation or a more complex mechanism.
The findings from our study are consistent with previous reports showing that women who breast-feed have a significant decrease in BMD at both the lumbar spine and the neck of femur compared with women who do not breast-feed. Low molecular weight heparin offers the important advantage of requiring less frequent administration compared with unfractionated heparin preparations.
In conclusion, pregnant women requiring thromboprophylaxis can be reassured that the loss in lumbar spine BMD associated with low-dose long-term heparin therapy is similar to that which occurs physiologically during pregnancy. Bone mineral density BMD measurements at 12 weeks gestation baseline and immediately postpartum in women treated with aspirin and heparin.
Demographic and clinical characteristics of women who received low-molecular-weight versus unfractionated heparin. Bone mineral density BMD changes during pregnancy in women who received low-molecular-weight versus unfractionated heparin. Bone mineral density BMD measurements pre-pregnancy and at 12 weeks gestation in nine women treated with aspirin and heparin.
We thank the women who participated in this study and Tracy McGrath, Clinic Co-ordinator, for her dedication to the Clinic, its staff and its patients. Altman, D. Chapman and Hall, London. Avioli, L. Backos, M. Barbour, L. Dahlman, T. Douketis, J. A prospective matched cohort study. Drinkwater, B. Bone Mineral. Fuller, K. Griffith, G. Griffith, H. Haram, K. Acta Obstet. Hurley, M. Bone Mineral Res. Kalkwarf, H. Khastgir, G. Kutteh, W. Nelson-Piercy, C. Rai, R. Shaughnessy, S.
Blood , 86 , — Shefras, J. Eur J. Smith, R. C, Winearls, C. Lancet , i , — Sowers, M. Squires, J. WHO Study Group Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Wise, P. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu.
Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Materials and methods. Her back pain improved. A repeat MRI was done after 4 months of treatment as she complained of back spasms, that showed well healed fracture. Discussion: Pregnancy and lactation are known risk factors for osteoporosis. Women with risk factors for secondary bone loss and fragility are at increased risk of fracture.
Long term use of heparin can cause bone loss by decreased formation and increased resorption. Bone loss can be seen after 6 months of therapy with heparin. Advanced Search. Privacy Copyright. Skip to main content. The results revealed that there is no significant difference in mean bone mineral density between a low-molecular-weight heparin prophylaxis group and a no prophylaxis group.
The study was not adequately powered to detect differences in absolute fracture risk. Summary: Recent results suggest that the use of long-term prophylactic low-molecular-weight heparin in pregnancy is not associated with a significant decrease in bone mineral density.
Whether higher doses might be a risk factor for osteoporosis is still an unanswered question.
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