He carried out much of his work in a house in Nottingham. Over the next decade, Dr Adams and his team tested various compounds - many of which failed - before they discovered 2- 4-isobutylphenyl propionic acid. A patent was filed in and further trials had to be made before it was licensed in as a prescription drug in the UK.
Sophie Clapp, company archivist at Boots, described him as a "key hero of Boots", adding: "He was a really significant figure in terms of the history of Nottingham and a remarkable figure in the history of Boots. He was a really lovely man. His discovery was a phenomenal achievement. Its pioneer, Stewart Adams, now 92 years old, tells Julia Robinson about how and why his discovery came to fruition. In , Boots UK sold an average of one pack of ibuprofen every 2. It took 16 years of tireless research before Adams finally made his breakthrough discovery.
But it began not with a quest to find a general painkiller, but to produce a new drug for rheumatoid arthritis. At the time there was little literature about aspirin, a discovery which came as a huge surprise to Adams. So, with the help of chemist John Nicholson, Adams set to work to do just that. The pair continued to test the potency of hundreds of other compounds, with some going to clinical trial and one even making it to market but, again and again, they came up against inactive compounds or unacceptable side effects.
He was right. It went to clinical trial. The painkiller became known as Ibuprofen. The invention of Ibuprofen arose out of a Boots study to treat rheumatoid arthritis before evolving into a drug to relieve a range of conditions.
Dr Stewart Adams was the project leader on the team which made the amazing discovery. From the start, Dr Adams had set out to find a drug that would be better tolerated than aspirin - the main painkiller on the market at that time. However, it needed to possess similar capacities to reduce pain and inflammation. Dr Adams began his work in a living room of a Victorian house on the outskirts of Nottingham - Boots' research department having been partially destroyed during World War Two bombing raids.
He and a technician meticulously calculated the compounds that would form the drug before they were joined by an organic chemist - Dr John Nicholson - who made them. Ibuprofen was launched on to the market in , with an over-the-counter version available from Dr Adams - now in his 80s - spent his life working at Boots, starting as a year-old apprentice in store before taking a degree in pharmacy at Nottingham University, followed by a PhD at Leeds.
After the invention of Ibuprofen, he had the chance to move to a number of different companies. However, he chose to see out his career with Boots. But the invention of Ibuprofen is just one of many amazing products invented by Boots experts over the years. And now, many of our fantastic healthcare brands - like Repel insect repellent - are being brought together with several new products under the brand: Boots Pharmaceuticals. Having worked at Boots for more than three decades, Paul is well aware that Boots scientists have hardly rested on their laurels since the invention of Ibuprofen.
We were the first to use a triple active for coughs and colds in our Daytime cold and flu relief product," he says. But it's not just in flu and pain relief that Boots has broken new ground. Our expertise spans across a massive range of healthcare products. Our range covers healthcare items like First Aid and Repel insect repellent but also includes positive healthcare such as vitamins and supplements.
We used to sell cod liver oil and echinacea in the 19th century and they are still popular today. Our expertise is constantly taking us into new areas And Boots Pharmaceuticals offers a broad range of options. Some products already existed, others - such as the Delay device - are the first of their type. Throughout Boots' history, trust has been an important part of our name, with Jesse Boot asking Boots experts to quality approve products from as early as And Jesse's team of trained pharmacists used to reject anything that didn't meet their standards.
If you know that a certain medicine helps relieve your dry skin, you're not likely to change. It's very rare for people to experiment with health products the way they will, for example, with beauty products.
One of those obstacles was, in fact, ibuprofen. Adams had originally set out to find a cure for rheumatoid arthritis. While he was obviously pleased with the success of ibuprofen, he was disappointed that he never developed a drug that would reverse the debilitating disease that affects millions of people.
Ibuprofen became an effective treatment for the disease, but it was no cure. Stewart Adams began his career in pharmaceuticals at the young age of 16, when he started an apprenticeship at a drug store owned by Boots UK Limited , then known as Boots the Chemist. He went on to earn a degree in pharmacy at the University of Nottingham and then received his PhD in pharmacology at the University of Leeds. Adams rejoined Boots in the research department in and started working on a cure for rheumatoid arthritis.
His goal was to develop something that was as effective as steroids but had none of the side effects. Adams began his research by studying how aspirin worked, which no one else was doing at the time.
Adams recruited Nicholson, a chemist, to help him test more than different compounds in hopes of finding one that could reduce inflammation and that most people could tolerate. They narrowed down the field to five drugs.
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